Kill your target and escape your pursuer in less than 10 seconds (Multiplayer Only).
During Open Conflict, kill your target and escape (Multiplayer Only).
Perform a double or triple escape (Multiplayer Only).
Take the lead 10 seconds before the end of a session and go on to win (Multiplayer Only).
Score 750 points or more on a single kill (Multiplayer Only).
Kill your target while hidden in a hay bale (Multiplayer Only).
Complete an entire Session with at least one kill (Multiplayer Only).
Replay a Memory.
Complete DNA Sequence 2.
Discover the Shrine in the Terme di Traiano.
Throw money in a well.
Find 1 Artifact in 2012.
Access your email in 2012.
Earn 3 gold medals in the Animus Virtual Training Program.
Find a secure place to hide and re-enter the Animus.
Complete DNA Sequence 1.
Attempt to access DNA Sequence 9 for the first time.
Complete DNA Sequence 8.
Complete DNA Sequence 9.
Secure the Apple of Eden.
Achieve 100% Synchronization in any Sequence other than Sequence 1.
Discover the Shrine in the Catacombe di Roma.
Discover the Shrine in Il Colosseo.
Discover the Shrine in the Cloaca Maxima.
Discover the Shrine in Palazzo Laterano.
Discover the Shrine in the Basilica di San Pietro.
Destroy the Machine Gun.
Destroy the Naval Cannon.
Destroy the Bomber.
Destroy the Tank.
Renovate 5 buildings in the Antico district.
Burn All Borgia Towers.
Complete 10 Guild Challenges.
Solve all of Subject 16's puzzles.
Recruit 3 Assassins.
Train a recruit up to the Rank of Assassin.
Remove All Borgia Flags in Rome.
Collect All Feathers.
Perform an Execution Streak of 10 kills.
Kill a guard with a broom.
Jump with the parachute off the top of Castel Sant'Angelo.
Win the highest bet at the Fights.
Reach Level 50 (Multiplayer Only).
Get all the Co-op bonuses in 1 session (Multiplayer Only).
Get every single bonus at least once (Multiplayer Only).
Complete DNA Sequence 3.
Throw a Long Weapon, Heavy Weapon, and Smoke bomb more than 10 m at a guard.
Win 10000 florins playing Hazard.
Receive 100% synch in ACB and full synch in all missions of the Da Vinci Disappearance.
Kill 10 guards with a single arrow storm.
Complete the Da Vinci Disappearance.
Beat up the 5 thirsty harlequins.
Double Assassinate from a parachute.
Steal 5 horses from their riders, while remaining on horseback.
Kill a guard with the bag that drops from a lift.
Complete DNA Sequence 4.
Pay 500 florins to an orator, then pickpocket him afterward.
Complete DNA Sequence 5.
Complete DNA Sequence 6.
Complete DNA Sequence 7.